解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::The aim of the present study was to investigate the expression, function and underlying molecular mechanism of the long non‑coding (lnc) RNA RP1‑163G9.1 in patients with gastric adenocarcinoma (GA). The expression levels of lncRNA RP1‑163G9.1 were determined in 112 paired clinical GA tissues by reverse transcription‑q...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2019.7127
更新日期:2019-06-01 00:00:00
abstract::Cervical cancer is the second most commonly diagnosed cancer in women. Novel prognostic biomarkers are required to predict the progression of cervical cancer. Cervical cancer expression data were obtained from The Cancer Genome Atlas (TCGA) database. MicroRNAs (miRNAs) significantly differentially expressed between ea...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2019.7097
更新日期:2019-06-01 00:00:00
abstract::Cyclin‑dependent kinase 5 regulatory subunit‑associated protein 3 (CDK5RAP3 or C53) is involved in the development of various types of tumor, and alternative splicing of C53 results in numerous transcription variants that encode different isoforms. The present study aimed to clone human C53 isoform d (IC53d) and expl...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2019.7042
更新日期:2019-05-01 00:00:00
abstract::Cisplatin (CDDP)‑based combination chemotherapy is the standard for muscle‑invasive bladder cancer (MIBC). However, nearly all patients undergoing CDDP chemotherapy become refractory due to the development of CDDP resistance. Therefore, clarification of the mechanisms of CDDP resistance is urgently needed. The transcr...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2019.7039
更新日期:2019-05-01 00:00:00
abstract::Tropomodulin 3 (TMOD3) is a member of the pointed‑end capping protein family that contributes to invasion and metastasis in several types of malignancies. TMOD3 has been found to be crucial for membranous skeleton and embryonic development; however, little is known regarding the role of TMOD3 in liver cancer progressi...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2019.7052
更新日期:2019-05-01 00:00:00
abstract::Head and neck squamous cell carcinoma (HNSCC) is the sixth most commonly diagnosed cancer worldwide. It has poor clinical outcome due to intrinsic or acquired drug resistance. Deregulation of both apoptosis and autophagy contributes to chemotherapy resistance and disease progression. A new member of the inhibitors of ...
journal_title:Oncology reports
pub_type: 杂志文章,评审
doi:10.3892/or.2019.7082
更新日期:2019-05-01 00:00:00
abstract::The nitrostyrene scaffold was previously identified as a lead target structure for the development of effective compounds targeting Burkitt's lymphoma. The present study aimed to develop these compounds further in haematological malignancies, including chronic lymphocytic leukaemia (CLL). Cellular viability, flow cyto...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2019.7068
更新日期:2019-05-01 00:00:00
abstract::Benign prostatic hyperplasia (BPH) is a common chronic disease in older males. The pathogenesis of BPH remains elusive but may be associated with chronic inflammation. Chemokines and chemokine receptors have been implicated as critical mediators in the immune response and inflammatory processes. In the present study, ...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2019.7002
更新日期:2019-04-01 00:00:00
abstract::Mesenchymal stem cells (MSCs) hold great promise as potential therapies for tumors through the delivery of various anticancer agents. However, exogenous tissue‑derived MSCs, such as those of bone marrow, have exhibited a tendency for malignant transformation in the tumor microenvironment. This issue remains controvers...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2019.7007
更新日期:2019-04-01 00:00:00
abstract::MicroRNAs (miRNAs or miRs) contribute to the development of various malignant neoplasms, including glioblastoma multiforme (GBM). The present study aimed to explore the pathogenesis of GBM and to identify latent therapeutic agents for patients with GBM, based on an in silico analysis. Gene chips that provide miRNA exp...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2019.7022
更新日期:2019-04-01 00:00:00
abstract::As a common malignancy of the endocrine system, papillary thyroid carcinoma (PTC) seriously affects the quality of life of patients. lncRNA PAX8‑AS1:28, or lnc‑PSD4‑1:14 has been reported to be abnormally expressed in PTC. However, the function of PAX8‑AS1:28 in PTC is still unknown. Therefore, the present study aimed...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2019.6996
更新日期:2019-04-01 00:00:00
abstract::Recently, emerging evidence shows that a number of long non‑coding RNAs (lncRNAs) recruit polycomb group (PcG) proteins to specific chromatin loci to silence relevant gene expression. In the present study, we provided evidence that lncRNA candidates, selected by bioinformatic analysis and nervous system polycomb 1 (NS...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2019.7000
更新日期:2019-04-01 00:00:00
abstract::Chromatin assembly factor 1 subunit B (CHAF1B) participates in DNA synthesis and repair. High CHAF1B expression has been associated with a poor prognosis in several types of cancers. However, no study has evaluated the clinical significance and biological function of CHAF1B in non‑small cell lung cancer (NSCLC). In th...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2019.6994
更新日期:2019-04-01 00:00:00
abstract::It has been revealed by our previous proteomic study that the expression profile is different between well‑differentiated and poorly differentiated hepatocellular carcinoma (HCC). Among those differently expressed proteins, peroxiredoxin2 (PRDX2) was our protein of interest. The present study aimed to further investig...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2019.6977
更新日期:2019-03-01 00:00:00
abstract::The aberrant expression of miR107‑5p is closely related to the development of several types of human cancers. However, the role of miR‑107‑5p in endometrial carcinoma (EC) has not been fully confirmed. In the present study, we aimed to explore the function of miR‑107‑5p in EC carcinogenesis. EC samples and normal endo...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2018.6936
更新日期:2019-03-01 00:00:00
abstract::The t(8;21) translocation is one of the most frequent chromosome abnormalities associated with acute myeloid leukaemia (AML). This abberation deregulates numerous molecular pathways including the ERK signalling pathway among others. Therefore, the aim of the present study was to investigate the gene expression pattern...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2018.6926
更新日期:2019-03-01 00:00:00
abstract::Oncolytic viruses are genetically engineered viruses designed for the treatment of solid tumors, and are often coupled with the antitumor immunity of the host. The challenge of using oncolytic herpes simplex virus (oHSV) as an efficacious oncolytic agent is the potential host tissue damage caused by the production of ...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2018.6935
更新日期:2019-03-01 00:00:00
abstract::Human glioblastoma is a malignant and aggressive primary human brain solid tumor characterized by severe hypoxia. Hypoxia can induce autophagy, which may result in chemoresistance and malignant progression of cancer cells. MicroRNAs (miRNAs) have been reported to modulate hypoxia‑induced autophagy in various types of ...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2018.6929
更新日期:2019-03-01 00:00:00
abstract::The present study investigated the expression and potential influence of SHC SH2 domain‑binding protein 1 (SHCBP1) in gastric cancer (GC) cells. SHCBP1 is closely related to cell proliferation and cell cycle progression, but its role in GC remains unclear. The TCGA database revealed that SHCBP1 is highly expressed in ...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2018.6952
更新日期:2019-03-01 00:00:00
abstract::Sulforaphane (SFN) was first isolated from broccoli sprout and it is present at high concentrations in plants belonging to the Cruciferae family. The chemotherapeutic and anti‑cancerogenic capacities of SFN have been demonstrated by inhibition of cancer cell proliferation in several cancer cell lines. The aim of the p...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2018.6919
更新日期:2019-02-01 00:00:00
abstract::miR-95 has been revealed to be aberrantly expressed in multiple types of cancer and to regulate tumor development. Moreover, miR-95 has been revealed to be downregulated in gastric cancer. However, the detailed function of miR-95 in gastric cancer has remained largely unknown. In the present study, we found that miR-9...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2018.6911
更新日期:2019-02-01 00:00:00
abstract::Reactive oxygen species (ROS) have been widely accepted as critical molecules playing regulatory roles in various biological processes, including proliferation, differentiation and apoptotic/ferroptotic/necrotic cell death. Emerging evidence suggests that ROS may be involved in the induction of epithelial‑to‑mesenchym...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2018.6905
更新日期:2019-02-01 00:00:00
abstract::Prostate cancer (PCa) is one of the most commonly diagnosed malignancies, and 90% of advanced prostate cancer patients relapse after therapy. Trophinin associated protein (TROAP) is essential for centrosome integrity and proper bipolar organisation of spindle assembly during mitosis and plays an essential role in prol...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2018.6854
更新日期:2019-02-01 00:00:00
abstract::P5, which is a member of the protein disulfide isomerase family, possesses isomerase and chaperone activity in vitro; however, the physiological functions of this enzyme in cells remain unclear. To understand the important roles of P5 in cancer cells, the present study examined its expression on the surface of normal ...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2018.6868
更新日期:2019-02-01 00:00:00
abstract::Increased production of reactive oxygen species (ROS) is a distinct feature of various types of cancer. ROS drive tumor progression and render cancer cells vulnerable to additional oxidative insult. The various natural herb compounds have been shown to induce additional production of ROS in cancer cells, although the ...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2018.6864
更新日期:2019-02-01 00:00:00
abstract::SET domain bifurcated 1 (SETDB1) is a histone H3 lysine 9 methyltransferase that is highly expressed in various tumor types, including breast cancer. However, how SETDB1 functions in breast cancer is unclear. In the present study, proliferation, migration and invasion assays were performed to explore the role of SETDB...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2018.6871
更新日期:2019-02-01 00:00:00
abstract::Prostate cancer (PCa) is the second most common type of male malignancy worldwide. The transcription factor zinc finger E‑box binding homeobox 1 (ZEB1) is associated with epithelial‑mesenchymal transition and is also involved in regulation of androgen receptor (AR) expression, the main ligands of which are testosteron...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2018.6885
更新日期:2019-02-01 00:00:00
abstract::Glutamine RF‑amide peptide (QRFP) belongs to the RFamide neuropeptide family, which is involved in a wide spectrum of biological activities, ranging from food intake and cardiovascular functioning to analgesia, aldosterone secretion, locomotor activity and reproduction. Recently, QRFP has been demonstrated to exert it...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2018.6893
更新日期:2019-02-01 00:00:00
abstract::Colorectal cancer (CRC) is the most commonly diagnosed tumor worldwide. However, the molecular mechanisms and biological processes of CRC remain unknown. The present study used reverse transcription-quantitative polymerase chain reaction to determine the expression levels of microRNA (miR)-296 in CRC cell lines and ti...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2018.6806
更新日期:2019-01-01 00:00:00
abstract::Notable advances in treatment have been made and increases in the cure rates of pediatric leukemia have been achieved. However, the majority of children with relapsed disease are not expected to survive, with chemotherapy resistance acting as the principal cause of treatment failure. Interaction between leukemic cells...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2018.6808
更新日期:2019-01-01 00:00:00
abstract::Galla Rhois is a commonly used medicine in East Asia for the treatment of several diseases. However, the effects of Galla Rhois on the metastasis of colorectal cancer (CRC) and the underlying molecular mechanisms have not been studied. We investigated the anti‑metastatic properties of Galla Rhois water extract (GRWE) ...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2018.6812
更新日期:2019-01-01 00:00:00
abstract::Oncolytic vaccinia virus is currently undergoing evaluation as a biological anticancer agent in clinical trials. This treatment exploits the lytic nature of a viral infection to eradicate the tumor mass in a cancer cell‑specific manner. So far, various vaccinia strains have been used as backbones in the design of onco...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2018.6801
更新日期:2019-01-01 00:00:00
abstract::Thyroid cancer is the most commonly diagnosed malignancy of the endocrine system, the incidence of which has increased rapidly in the last 30 years. Genetic alterations in pathways, including the mitogen‑activated protein kinase (MAPK)/extracellular signal‑regulated kinase (Erk) and phosphatidylinositol‑3‑kinase (PI3K...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2018.6807
更新日期:2019-01-01 00:00:00
abstract::Gastric cancer is currently the fourth most common cancer and the third leading cause of cancer‑associated mortality worldwide. Studies have identified that certain biomarkers contribute to the prognosis, diagnosis and treatment of gastric cancer. However, the biomarkers of gastric cancer are rarely used clinically. T...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2018.6794
更新日期:2019-01-01 00:00:00
abstract::The tumor microenvironment plays an important role in cancer growth, invasion and metastasis. The stroma surrounding a tumor is known to contain a variety of factors that can increase angiogenesis, cancer growth and tumor progression. The aim of the present study was to determine the role of fascin in cancer growth an...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2018.6847
更新日期:2019-01-01 00:00:00
abstract::Glioblastoma is the most common type of primary brain tumour in adults, and its pathogenesis is particularly complicated. Among the many possible mechanisms underlying its pathogenesis, hyperactivation of the PI3K/Akt pathway is essential to the occurrence and development of glioma through the loss of PTEN or somatic ...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2018.6845
更新日期:2019-01-01 00:00:00
abstract::Exhausted cluster of differentiation (CD)8+ T cells lose immunological activity due to mitochondrial dysfunction caused by peroxisome proliferator‑activated receptor γ coactivator 1α (PGC‑1α) inactivation, resulting in a poor prognosis in patients with cancer. As hydrogen gas was recently reported to activate PGC‑1α, ...
journal_title:Oncology reports
pub_type: 杂志文章,随机对照试验
doi:10.3892/or.2018.6841
更新日期:2019-01-01 00:00:00
abstract::Juvenile myelomonocytic leukemia (JMML) is a rare but severe primary hemopoietic system tumor of childhood, most frequent in children 4 years and younger. There are currently no specific anticancer therapies targeting JMML, and the underlying gene expression changes have not been revealed. To define molecular targets ...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2018.6709
更新日期:2018-12-01 00:00:00
abstract::The incidence of well‑differentiated thyroid cancer (WDTC) is rapidly increasing. Poor survival follows distant metastasis (DM) and recurrence. In the present study, we aimed to analyze the expression alterations in different stages of WDTC and the regulatory mechanism of DM and the recurrence of DM. A male patient di...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2018.6739
更新日期:2018-12-01 00:00:00
abstract::Acquisition of resistance to paclitaxel is a major obstacle to successful treatment of breast cancer patients, but the molecular mechanisms underlying the development of drug resistance remain largely unclear. The aim of the present study was to investigate the role and mechanism of action of miR‑200c‑3p in the resist...
journal_title:Oncology reports
pub_type: 杂志文章
doi:10.3892/or.2018.6735
更新日期:2018-12-01 00:00:00